Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.

نویسندگان

  • David Zhuang
  • Melinda Smedema
  • Ann Lemonte
  • Benita K Book
  • Mark D Pescovitz
  • L Joseph Wheat
چکیده

Calcineurin inhibitors may augment the effects of antifungal drugs in microbiological assays. We examined this interaction in a microbiological assay for posaconazole. No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 2  شماره 

صفحات  -

تاریخ انتشار 2008